Alzheimer's disease is characterized by amyloid-beta peptide -loaded plaques in the brain. Abeta is a cleavage fragment of amyloid-beta protein precursor and over production of APP may lead to amyloidogenesis. The regulatory region of the APP gene contains consensus sites recognized by the transcription factor, specificity protein 1 , which has been shown to be required for the regulation of APP and Abeta. To understand the role of SP1 in APP biogenesis, herein we have characterized the relative distribution and localization (...) of SP1, APP, and Abeta in various brain regions of rodent and primate models using immunohistochemistry. We observed that overall distribution and cellular localization of SP1, APP, and Abeta are similar and neuronal in origin. Their distribution is abundant in various layers of neocortex, but restricted to the Purkinje cell layer of the cerebellum, and the pyramidal cell layer of hippocampus. These findings suggest that overproduction of Abeta in vivo may be associated with transcriptional pathways involving SP1 and the APP gene. (shrink)

Oxidative damage to DNA has been associated with neurodegenerative diseases. Developmental exposure to lead has been shown to elevate the Alzheimer's disease related beta-amyloid peptide , which is known to generate reactive oxygen species in the aging brain. This study measures the lifetime cerebral 8-hydroxy-2'-deoxyguanosine levels and the activity of the DNA repair enzyme 8-oxoguanine DNA glycosylase in rats developmentally exposed to Pb. Oxo8dG was transiently modulated early in life , but was later elevated 20 months after exposure to Pb (...) had ceased, while Ogg1 activity was not altered. Furthermore, an age-dependent loss in the inverse correlation between Ogg1 activity and oxo8dG accumulation was observed. The effect of Pb on oxo8dG levels did not occur if animals were exposed to Pb in old age. These increases in DNA damage occurred in the absence of any Pb-induced changes in copper/zinc-superoxide dismutase , manganese-SOD , and reduced-form glutathion . These data suggest that oxidative damage and neurodegeneration in the aging brain could be impacted by the developmental disturbances. (shrink)

Alzheimer's disease is characterized by plaques of amyloid-beta peptide, cleaved from amyloid-beta protein precursor . Our hypothesis is that lifespan profiles of AD-associated mRNA and protein levels in monkeys would differ from mice and that differential lifespan expression profiles would be useful to understand human AD pathogenesis. We compared profiles of AbetaPP mRNA, AbetaPP protein, and Abeta levels in rodents and primates. We also tracked a transcriptional regulator of the AbetaPP gene, specificity protein 1 , and the beta amyloid precursor (...) cleaving enzyme . In mice, AbetaPP and SP1 mRNA and their protein products were elevated late in life; Abeta levels declined in old age. In monkeys, SP1, AbetaPP, and BACE1 mRNA declined in old age, while protein products and Abeta levels rose. Proteolytic processing in both species did not match production of Abeta. In primates, AbetaPP and SP1 mRNA levels coordinate, but an inverse relationship exists with corresponding protein products as well as Abeta levels. Comparison of human DNA and mRNA sequences to monkey and mouse counterparts revealed structural features that may explain differences in transcriptional and translational processing. These findings are important for selecting appropriate models for AD and other age-related diseases. (shrink)

The sporadic nature of Alzheimer's disease argues for an environmental link that may drive AD pathogenesis; however, the triggering factors and the period of their action are unknown. Recent studies in rodents have shown that exposure to lead during brain development predetermined the expression and regulation of the amyloid precursor protein and its amyloidogenic beta-amyloid product in old age. Here, we report that the expression of AD-related genes [APP, BACE1 ] as well as their transcriptional regulator were elevated in aged (...) monkeys exposed to Pb as infants. Furthermore, developmental exposure to Pb altered the levels, characteristics, and intracellular distribution of Abeta staining and amyloid plaques in the frontal association cortex. These latent effects were accompanied by a decrease in DNA methyltransferase activity and higher levels of oxidative damage to DNA, indicating that epigenetic imprinting in early life influenced the expression of AD-related genes and promoted DNA damage and pathogenesis. These data suggest that AD pathogenesis is influenced by early life exposures and argue for both an environmental trigger and a developmental origin of AD. (shrink)

Parkinson's Disease (PD) is a long-term degenerative disorder of the central nervous system that mainly affects the motor system. The symptoms generally come on slowly over time. Early in the disease, the most obvious are shaking, rigidity, slowness of movement, and difficulty with walking. Doctors do not know what causes it and finds difficulty in early diagnosing the presence of Parkinson’s disease. An artificial neural network system with back propagation algorithm is presented in this paper for helping doctors in identifying (...) PD. Previous research with regards to predict the presence of the PD has shown accuracy rates up to 93% [1]; however, accuracy of prediction for small classes is reduced. The proposed design of the neural network system causes a significant increase of robustness. It is also has shown that networks recognition rates reached 100%. (shrink)

Can politics be studied scientifically, and if so, how? Assuming it is impossible to justify values by human reason alone, social science has come to consider an unreflective relativism the only viable basis, not only for its own operations, but for liberal societies more generally. Although the experience of the sixties has made social scientists more sensitive to the importance of values, it has not led to a fundamental reexamination of value relativism, which remains the basis of contemporary social science. (...) Almost three decades after Leo Strauss's death, Nasser Behnegar offers the first sustained exposition of what Strauss was best known for: his radical critique of contemporary social science, and particularly of political science. Behnegar's impressive book argues that Strauss was not against the scientific study of politics, but he did reject the idea that it could be built upon political science's unexamined assumption of the distinction between facts and values. Max Weber was, for Strauss, the most profound exponent of values relativism in social science, and Behnegar's explication artfully illuminates Strauss's critique of Weber's belief in the ultimate insolubility of all value conflicts. Strauss's polemic against contemporary political science was meant to make clear the contradiction between its claim of value-free premises and its commitment to democratic principles. As Behnegar ultimately shows, values--the ethical component lacking in a contemporary social science--are essential to Strauss's project of constructing a genuinely scientific study of politics. (shrink)

This article aims to read feminist new materialisms (Barad), together with ‘postulated’ linguistic or cultural primacy of Queer Theory (Butler), to show how both are engaged in similar critical-ethical endeavours. The central argument is that the criticism of Barad and new materialisms misses Butler’s materialistic insights due to a narrow interpretation of Butler's alleged social-constructivist position. There is, therefore, a specific focus on where they both make similar ethical appeals. Moreover, the article relies on Adorno's negative dialectic to highlight an (...) interpretation of Barad and Butler as being part of the same dialectical movement, in which materialism and idealism fluctuate in their mutual criticisms, thus continuing the procession towards 'new knowledge' and emancipation, or freedom, through their motions back and forth. (shrink)

The two potential public spaces of political expression in the city, the mosque and the plaza, were denied their civic function for anywhere between thirty and fifty years of despotic rule across the Arab world depending on the country. Abrupt and violent revolts sometimes managed to stage their protests in one or the other for a short moment, but the reprisal of the regime was usually swift and ruthless.

Throughout this research, imposing the training of an Artificial Neural Network (ANN) to play tic-tac-toe bored game, by training the ANN to play the tic-tac-toe logic using the set of mathematical combination of the sequences that could be played by the system and using both the Gradient Descent Algorithm explicitly and the Elimination theory rules implicitly. And so on the system should be able to produce imunate amalgamations to solve every state within the game course to make better of results (...) of winnings or getting draw. (shrink)

: Mu1ammad Taqiyy al-Dīn al-Maqrīzī is undoubtedly the historian with the most expansive repertoire of the entire fifteenth century Arabic historiography. His al-Mawā’iẓ wa-l-i’tibār bi-dhikr al-khiṭaṭ wa-l-āthār, in particular, is a unique achievement, which manages to present a general historical discourse through the chronicling of buildings and topography. This unprecedented book, this paper argues, may have benefited from the author’s extended association with Ibn Khaldūn, the great interpreter of the notion of ’umrān. Ibn Khaldūn was al-Maqrīzī’s revered teacher for at (...) least thirty years. He seems to have influenced his pupil’s thinking about the city as the domain of civilization in two ways: analytical, that is to look for causes and effects behind events and appearances, and interpretive, that is to see in the urban and architectural history of the city the illustration of the underlying civilizational cycle. In the Khiṭaṭ, al-Maqrīzī seems to have applied his master’s theory to a concrete example – the city of Cairo – and drew from it pronounced moral lessons on the decline he was observing in the Mamlūk sultanate. This is probably why the Khiṭaṭ’s influence has endured for more than five centuries: a tribute to its author’s ardent passion and filial affinity with his city and country, as well as his interpretive framework, which he probably absorbed from Ibn Khaldūn. (shrink)

The Road Inns in Bilād al-Shām. By Katia Cytryn-Silverman. BAR S2130. Oxford: Archaeopress, 2010. Pp. vi + 290, illus. £58.

Changes in the past two decades of goals for science education in schools have induced new orientations in science education worldwide. One of the emerging complementary approaches was the science-technology-society (STS) movement. STS has been called the current megatrend in science education. Others have called it a paradigm shift for the field of science education. The success of science education reform depends on teachers' ability to integrate the philosophy and practices of current programs of science education reform with their existing (...) philosophy. Thus, when considering the STS approach to science education, teacher beliefs about STS implementation require attention. Without this attention, negative beliefs concerning STS implementation and inquiry learning could defeat the reform movements emphasizing STS. This article argues the role of STS in science education and the importance of considering science teachers' beliefs about STS in implementing significant reforms in science education. (shrink)

In this paper an Artificial Neural Network (ANN) model, for predicting the category of a tumor was developed and tested. Taking patients’ tests, a number of information gained that influence the classification of the tumor. Such information as age, sex, histologic-type, degree-of-diffe, status of bone, bone-marrow, lung, pleura, peritoneum, liver, brain, skin, neck, supraclavicular, axillar, mediastinum, and abdominal. They were used as input variables for the ANN model. A model based on the Multilayer Perceptron Topology was established and trained using (...) data set which its title is “primary tumor” and was obtained from the University Medical Centre, Institute of Oncology, Ljubljana, Yugoslavia Test data evaluation shows that the ANN model is able to correctly predict the tumor category with 76.67 % accuracy. (shrink)

Comment penser les processus d’interactions culturelles? L’analyse du monde arabe est réduite trop souvent à l’analyse conjoncturelle de ces relations, elle contient trop souvent en elle-même un chauvinisme de l’universel. En effet, la force de l’idéologie de l’immédiateté, c’est sa capacité à domestiquer notre point de vue. Cela présuppose que la confiance commune de sujet connaissant est si forte que notre lecture de l’immédiat est corrélée par une analyse aussi rapprochée en termes de temps que l’événement lui-même et son commentaire. (...) Et pourtant bien que notre savoir se réduise en qualité de pensée, nous n’avons aucune difficulté pour dire que nous savons. Mais que savons-nous au juste à propos des relations de l’interculturalité pratique? Comment penser sans narcissisme idéologique ou ethnocentrisme scolastique, les cultures politiques extra-occidentales? Pour cela, il s’agit de se défaire du prisme des aires culturelles et de reposer à nouveau la question de l’expérience de l’universel. (shrink)

Comment penser les processus d’interactions culturelles? L’analyse du monde arabe est réduite trop souvent à l’analyse conjoncturelle de ces relations, elle contient trop souvent en elle-même un chauvinisme de l’universel. En effet, la force de l’idéologie de l’immédiateté, c’est sa capacité à domestiquer notre point de vue. Cela présuppose que la confiance commune de sujet connaissant est si forte que notre lecture de l’immédiat est corrélée par une analyse aussi rapprochée en termes de temps que l’événement lui-même et son commentaire (...) (par exemple les termes antagonistes : « Occident versus Orient », « guerre de civilisations »). Et pourtant bien que notre savoir se réduise en qualité de pensée, nous n’avons aucune difficulté pour dire que nous savons. Mais que savons-nous au juste à propos des relations de l’interculturalité pratique? Comment penser sans narcissisme idéologique ou ethnocentrisme scolastique, les cultures politiques extra-occidentales? Pour cela, il s’agit de se défaire du prisme des aires culturelles et de reposer à nouveau la question de l’expérience de l’universel. (shrink)

As future citizens, students must make decisions requiring an understanding of the interaction of science and technology and its interface with society. STS education has been strongly identified with meeting this goal, but putting theory into practice has so far been difficult. This article asks, “What are the challenges influencing science teachers to implement STS education in the science classroom?” The author investigated using a mixed method research technique incorporating multiple sources of qualitative and quantitative data (questionnaire, interviews, field notes, (...) and classroom observations). Constraints a fecting teachers' practices in teaching science through STS education were identified and can be categorized into impersonal, interpersonal, and personal constraints. Findings indicated interactions within and between external and internal constraints. Suggestions are made for implementing change in various aspects of science teacher education. (shrink)

La discapacidad ha sido concebida a lo largo del tiempo de diferentes modos, lo cual fue ocasión para que algunos autores construyeran modelos para explicar ciertas praxis en torno al tema. Este artículo traza un recorrido desde el primer modelo hasta la actualidad. A su vez propone un nuevo, el Modelo de Comunicación y Reconocimiento Legítimo de la Discapacidad (MCRLD), el cual se caracteriza por un cambio de paradigma: pasar de la inclusión al reconocimiento. Para fundamentar esto, se presentan sus (...) tres categorías: reconocimiento, distancia y vulnerabilidad. También se expondrán las diferentes teorías y conceptos que lo sustentan. El propósito del MCRLD es profundizar en la idea del empoderamiento de las personas con discapacidad como parte de la diversidad de la sociedad, acortando brechas históricamente construidas y aún vigentes. (shrink)

Buildings energy consumption is growing gradually and put away around 40% of total energy use. Predicting heating and cooling loads of a building in the initial phase of the design to find out optimal solutions amongst different designs is very important, as ell as in the operating phase after the building has been finished for efficient energy. In this study, an artificial neural network model was designed and developed for predicting heating and cooling loads of a building based on a (...) dataset for building energy performance. The main factors for input variables are: relative compactness, roof area, overall height, surface area, glazing are a, wall area, glazing area distribution of a building, orientation, and the output variables: heating and cooling loads of the building. The dataset used for training are the data published in the literature for various 768 residential buildings. The model was trained and validated, most important factors affecting heating load and cooling load are identified, and the accuracy for the validation was 99.60%. (shrink)

Lorsque la vie apparaît comme une oeuvre d'art au plein sens du terme, elle est alors portée par ce geste d'invention de soi, geste de résistance qui déplace les lignes de force, qui vise la récupération du monde à travers une subjectivité révolutionnaire. Une des caractéristiques fondamentales de l'homme est l'altérité et l'étrangeté. Exposé à l'inconnu, il est amené à déployer son existence au-delà d'une origine ou d'un foyer. Il est acculé à puiser en lui des ressources insoupçonnées pour faire (...) face aux turbulences de l'être. Cela confère une liberté de mouvement que donnent à voir des trajectoires d'hommes exceptionnels dotés d'un courage et d'une puissance de pensée pour tracer de nouveaux chemins. Cela ne va pas sans crise de l'intériorité, sans destruction des frontières de la subjectivité faisant de l'homme un étranger sans repos et sans assise. Mais c'est dans l'échappée à la tyrannie du même que la mutation survient avec une conscience ouverte aux réalités les plus étrangères. A ce niveau se situe la lutte perpétuelle dont parle Nietzsche qui vise une transformation radicale de l'individualité. Le regard de l'étranger se situe dans cette ligne de fuite qui bouleverse les modalités du voir, propulsant l'âme vers des horizons stupéfiants à travers une puissance de la pensée où le sujet est désormais porté par l'infini de l'être. (shrink)

Philosophers ask just whose expression, if anyone’s, we hear in lyric poetry. Walton provides a novel possibility: it’s the reader who “uses” the poem (just as a speech giver uses a speech) who makes the language expressive. But worries arise once we consider poems in particular social or political settings, those which require a strong self-other distinction, or those with expressions that should not be disassociated from the subjects whose experience they draw from. One way to meet this challenge is (...) to consider the poem expressive of a plural subject, which frees us from looking for a particular individual whose voice we hear in the work, whether she be fictional or actual. Some lyrics give voice to a group whose experience is attended to in the work. This may be done through a posited fictional speaker, but the ontology of the speaker is shown to be less important. Attending to a group whose concerns are voiced allows us to explain how poems can manage to address our-worldly concerns even when lacking actual persons whose expressions we encounter in the poems. (shrink)

This is a study of the nature of time. In it, redeploying an argument first presented by McTaggart, the author argues that although time itself is real, tense is not. He accounts for the appearance of the reality of tense - our sense of the passage of time, and the fact that our experience occurs in the present - by showing how time is indispensable as a condition of action. Time itself is further analysed, and Dr Mellor gives answers to (...) most of the metaphysical questions it provokes, concerning the relation of time to space, the dissection of time, and its relation to change and causation. (shrink)

In a detailed and spirited critique, Professor James M. Humber has found my defence of the ontological argument unconvincing. Humber's case rests upon his claim that my ‘error’ is due to my ‘having accepted an incorrect definition of “physically necessary being” … ’. Now I do indeed claim that God must be conceived as a factuall necessary being, i.e. as eternally independent. I take the notion of God's aseity or eternal independence to be relatively straightforward and uncontroversial; it is accepted (...) as an essential component of the concept God by many philosophers who also insist that there is no acceptable form of demonstrative theism. Thus, it is widely held that ‘God is a factually necessary being’ does not imply ‘God is a logically necessary being’; that God is eternally independent does not imply that he exists in all possible worlds. But it is precisely this view that I have argued is incorrect. While I concur that there is an intelligible concept of God as factually necessary, I deny that the existence of such a being is logically contingent, a mere matter of empirical fact. Indeed, a rigorous inspection of the concept of an eternally independent being reveals that whether that concept is instantiated, i.e. whether there exists a being exemplifying that concept, is knowable a priori . My claim is in fact stronger than this. I argue that the existence of an eternal, independent, omniscient and omnipotent being is demonstrable by conceptual analysis. It is Humber's contention that my alleged demonstration of God's existence crumbles upon the discovery of the unacceptability of my definition of ‘factually necessary being’. Let us see. (shrink)

This article examines the cultural meanings of suicide, self-sacrifice, military and terrorist violence in the context of contemporary Israel, Palestine and the U.S. ‘War on Terror’. Notions of ‘sacrifice’ and ‘suicide’, employed in the anthropological and sociological literature, are evaluated with regard to these materials using a theoretical framework for interpreting violent acts as part of cultural expression and as critically linked to collective imagination and memory. This theoretical approach is then also deployed to re-examine other apparently unintelligible forms of (...) violence, such as school-shootings, serial-killing in the U.S., as well as ethnic-cleansing and community violence elsewhere. (shrink)

The liver is the human body’s mandatory organ, but detecting liver disease at an early stage is very difficult due to the hiddenness of symptoms. Liver diseases may cause loss of energy or weakness when some irregularities in the working of the liver get visible. Cancer is one of the most common diseases of the liver and also the most fatal of all. Uncontrolled growth of harmful cells is developed inside the liver. If diagnosed late, it may cause death. Treatment (...) of liver diseases at an early stage is, therefore, an important issue as is designing a model to diagnose early disease. Firstly, an appropriate feature should be identified which plays a more significant part in the detection of liver cancer at an early stage. Therefore, it is essential to extract some essential features from thousands of unwanted features. So, these features will be mined using data mining and soft computing techniques. These techniques give optimized results that will be helpful in disease diagnosis at an early stage. In these techniques, we use feature selection methods to reduce the dataset’s feature, which include Filter, Wrapper, and Embedded methods. Different Regression algorithms are then applied to these methods individually to evaluate the result. Regression algorithms include Linear Regression, Ridge Regression, LASSO Regression, Support Vector Regression, Decision Tree Regression, Multilayer Perceptron Regression, and Random Forest Regression. Based on the accuracy and error rates generated by these Regression algorithms, we have evaluated our results. The result shows that Random Forest Regression with the Wrapper Method from all the deployed Regression techniques is the best and gives the highest R2-Score of 0.8923 and lowest MSE of 0.0618. (shrink)

Purpose Moor designated two major problem sources typifying the social and ethical implications of computer technologies, namely, “policy vacuum” and “conceptual muddles.” Motivated by Moor’s seminal definition and Floridi’s conceptualization of information and communication technologies as re-ontologizing technologies, this study aims to explore Omani undergraduates’ cognition regarding ICT ethics. Design/methodology/approach Adopting a grounded theory approach for the constant comparative thematic analysis, the constituents of ICT ethics-related cognition among undergraduates and influencing factors were scrutinized. Qualitative data were gathered via focus group (...) discussions with undergraduates and interviews with academics and information systems professionals at Sultan Qaboos University. Findings In total, 10 thematic categories revolving around a core category, constructing conceptual perceptions of and attitudes toward the realms constituting ICT ethics using an ontological, object-oriented approach, emerged from the comparative analysis. Undergraduates were found to adopt an applied approach when defining professional ICT ethics codes and policies, with a particular focus on information privacy and integrity. Research limitations/implications This qualitative study was conducted at a single research site. This may restrict the generalizability of the findings. Postgraduates were not considered when designing this qualitative inquiry. Originality/value The findings of the study hold theoretical and methodological significance with regard to ICT ethics-related cognition in the era following the fourth industrial revolution by sustaining feminist ethics in this research. Ultimately, the study developed a substantive theory scrutinizing the constitutive elements of ICT ethics-related cognition among Generation Z. (shrink)